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While the direct activation of microglial TLRs by microbial metabolites remains to be tested, neuraminidase from bacteria and viruses was shown to induce inflammatory phenotypes in microglia through TLR2 and TLR4 [215]

The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading

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Regulatory trials and post-market data show that GLP-1 medications maintain steady appetite suppression and blood sugar effects across a 7 to 10-day window after injection, providing a natural buffer for minor timing variations